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Suzy-Cohen-1
Dear Pharmacist,
I take Zoloft for depression. It doesn‘t seem to work as well anymore. I also have a chronic illness, which I’d rather not disclose. Can Zoloft lose it’s effect like this?
M.B., Sanibel, Florida

Answer:  Yes. Sometimes we grow tolerant to a drug so it seems like the magic effect is gone. Or a drug could remain fully potent, while the body continues to decline because underlying imbalances do not get corrected. Chronic illness often goes hand in hand with poor sleep, stress and pain so treating these will also help improve depression. Since Zoloft isn’t helping anymore, try 5-HTP, a natural over-the-counter antidepressant.

Our body make 5-HTP which gets converted to serotonin, our “happy” brain chemical. 5-HTP is particularly good at balancing mood, improving sleep and reducing pain. It cuts carb cravings, reduces appetite and helps migraines. Each dose of 5-HTP should be taken 2 hours before meals with a snack or with orange juice. Caution: Don’t take 5-HTP with other antidepressants or if pregnant or nursing. And don’t overdue it. When starting, go slow and move upward towards a total daily dose of 300 – 600 mg per day.

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7 Comments
  • Sharon says:

    Can you take HTP-5 with Bupropion HCL XL?

    Thanks, Sharon
    Jacksonville, Fl

  • Mary Smith says:

    I would like to know about Black Cohosh Root and Niacin. I take these two Vitiams.

    I have an ulcer which I take Omeprazole 20mg.

    Please give me some advice

    Thank You
    Mary Frnces

  • Lucia says:

    Dear Suzy

    I just discovered your web site and
    found it very helpful and clear – congratulations!!
    I am 65 and currently trying to get some help with fibromyalgia, hypertension, hypercholesterolemia, depression, osteoporosis that plagued me for years. I exercise and my weight is normal. I received the battery of tests( normal) and medications including Simvastatin, low dose of anti hypertensives, antidepressants, Fosamax for 5 years which did not stop the progress of osteoporosis. My biggest fear is of brain atrophy that has been associated with Fibromyalgia.
    I heard that the use of bioidentical hormones, Forteo and / or Human Growth Hormone may help.
    Do you have any thoughts ?
    My best regards
    Lucia

  • Zoe says:

    Foreto? Isn’t that the procedure for depression, I had a friend who had this and she lost her memory she got some of it back but not all, still her husband has to tell her that she has been somewhere or ate something etc… but she can’t remember, I think that is terrible,

  • I am so glad I found this site, I have cronic pain and do not want to take alot of pain medication, I know some of them are addictive. I will try what yo have mentioned for pain management and I will definitely get back to you, letting you know how I feel in a week.

  • Darlene says:

    Iam so glade to fine this, I have fibromyalgia,high blood perusre and depression I take Exffexor xr for some years now Iam also losting my memory , thigs that I do all the time that I should know,that is really scaring me. I tryed 5-HTP and I got sores in my mouth. I would like to get off of all medication, I just don’t know what to do at this point, please help

  • sarah says:

    I saw you on “Know the cause”. I have been suffering from depression it is hereditary. I dont believe in drugs i hear it can mess your body up really bad but I need help surviving everyday life which can be stressful. Have you ever hear of Serotine. not sure i speled it right. or any other suggestions would be fine thank you

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